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Local Interventional Radiologists Deliver Minimally-Invasive Solutions

From the very beginning of my new normal, which began on June 11, 2009 when Dr. Ken Ogan used a DaVinci robot to surgically remove my diseased left kidney and 12 lymph nodes, I was left with an incurable case of renal cell carcinoma (RCC) and the stark realization that my job was to seek out the very best medical care I, with my great medical insurance and the shallow pockets of a small business owner, could afford. I had to use whatever medical wisdom was in existence to stay alive long enough to be strong enough to endure a more meaningful treatment if and when it came along.

To date, an initial occurrence and six separate subsequent battles with RCC mets have not managed to take me out and one of those “more meaningful treatments” was available to me locally and I have been fortunate enough to have been rendered NED (No Evidence of Disease) for the 7th time.

Here is a brief recap of the procedures (except for listing all CT/MRI scans, which have continued to occur at about 3 – 6 month intervals, depending on what was going on) and decisions we’ve made that got us to the office of Dr. Nishant DeQuadros:

June 11, 2009: Dr. Ken Ogan at Emory University Hospital performed radical left nephrectomy + 12 lymph nodes (1 positive for RCC).

August, 2009:  Started ASSURE clinical trial (Sutent/Nexavar/Placebo) and ultimately completed trial.

September, 2010: Discovered 2 cm tumor in spine at L-2, and was unblinded from placebo arm of clinical trial. Drawing the placebo arm of the trial turned out to be the good news, in that going forward I would be drug naive, allowing me more access to other therapies.

October 21, 2010: Biopsy of spine determined the lesion is metastatic RCC.

December 2, 2010: Stereotactic Radiosurgery (SRS) at Emory Midtown Hospital in Atlanta

March, 2010: Radiation oncologist says that I’m NED.

August, 2011: Medical oncologist says the tumor at L-2 wasn’t completely killed and it is growing again.

August 19, 2011: Lumbar fusion surgery and fixation with pedicle screws and fusion with bone morphogenic protein at L 1-3. Three weeks post surgery, developed severe (#10) back pain. Treated with time-released morphine and dilaudid for breakthrough pain. These weeks of pain and insomnia were the darkest days of my life. As I write this, I’m having trouble conjuring what the pain felt like. What it was like to be just aware enough to see the little hand of the clock find every click on its way around the dial, yet gladly not aware enough to be forced to remember some of the truly stupid television shows and movies I watched. Alone in a dark room with my ever-present plastic trash can, a box of tissues, a glass of water and a sack full of narcotics. The world looks very different from that room.

October 8, 2011: Some time before 5 a.m., I bent over to remove power plug from wall socket and experienced a dramatic loss of strength on my right side. I contacted my neurosurgeon, Dr. Michael Gorum, early Saturday morning. He instructed me to get to the emergency department immediately. His partner, Dr. Marc Goldman met me and we went immediately to surgery, where he performed a lumbar laminectomy (bilateral inferior L1, complete bilateral L2 and bilateral superior L3). Pain was immediately gone and according to physical therapist, the strength can be regained in legs with therapy. Two major spine surgeries within 8 weeks and a quickly-growing kidney cancer metastatic tumor trying its best to put me down.

October 10, 2011: I was moved by ambulance to the John B. Amos Cancer Center, where I was evaluated for stereotactic radiosurgery to attempt to kill the tumor in my back and returned to my room at the hospital. Got food poisoning (Yes, the day after my second back surgery in eight weeks! Can you believe it?) from a non-hospital meal I ate on Monday evening, so we delayed SRS until Thursday,

October 20, 2011: 16-greys of radiation in a single one-hour treatment aimed to kill the tumor in my spine.

October 26, 2011: Started monthly Xgeva injections to prevent further bone mets.

December 7, 2011: CT scans show NED.

March 15, 2012: CT scans show NED.

June 21, 2012: CT scan showed 3.9 cm tumor on left adrenal gland and slight enlargement of cyst in right kidney.

July 16, 2012: Decided to confer with specialists at M. D. Anderson in Houston, Tex. and met with genitourinary medical oncologist Dr. Lance Pagliaro there at M. D. Anderson.

July 17 – 18, 2012: Had bone scan, brain MRI, CT of chest, abdomen and pelvis with no contrast and a chest x-ray.

July 20, 2012: Met with interventional radiology to discuss needle biopsy of adrenal tumor.

July 25, 2012: Still at M. D. Anderson and needle biopsy of left adrenal tumor confirmed it was metastatic renal cell carcinoma.

September 3, 2012: Started HD-IL2 therapy at Duke University Hospital under care of Dr. Dan George and Dr. Michael Morse. Received 9 doses and creatinine spiked and didn’t come back to my baseline of 1.8, so I washed out. They wouldn’t allow me to finish part B of round one.

October 19, 2012: Had CT of chest, abdomen and pelvis W/O contrast, because of high creatinine.

October 26, 2012: Met with Dr. Pippas and found out adrenal tumor and nodules in kidney are stable. He recommends starting a TKI and plans to confer with Dr. George to determine which one they recommend.

November 13, 2012: Started with 800mg daily dose of Votrient. Took for 2 weeks and high blood pressure and other side effects caused oncologist to reduce daily dosage to 400mg. On 400mg dose for 3 weeks, increased to 600mg dose for 2 weeks and now on 800mg dose daily and dealing with side effects well.

July 11, 2013: CT scan of chest, abdomen and pelvis (W/O contrast) showed 90% reduction in adrenal tumor, no sign of two small right kidney lesions. Have lost 80 pounds due to GI complications with Votrient, but getting along fairly well. Have been able to stop taking Norvasc completely and have halved my daily Coreg dosage. Getting great blood pressure control, likely due to dramatic weight loss. Creatinine also looks good at about 1.5. So, might be able to get CT scans with contrast next time out.

November 1, 2013: CT scan with contrast of chest, abdomen and pelvis showed NED! Have lost 90 pounds due to GI complications of 800 daily mg of Votrient. Creatinine at 1.32 and other labs looks fantastic.

January 14, 2014: Have lost 100 pounds. Blood pressure is rising and with weight loss, this shouldn’t be the case. Hovering at around 180/115. So, went by to see Dr. Pippas to check blood pressure and they decided to triage me and work me in to see the doctor. Warned me that if I’m developing liver toxicity, we’ll have to make some changes. Had liver panel blood work done in lab. Dr. Pippas TOLD me to stop taking Votrient for 14 days and to take 20mg Prilosec every morning for next 14 days. Says he hopes my body will reset and that I can go back on Votrient after 2 weeks. Also, he added back 5mg of Norvasc to my daily meds to see if we can drive back the elevated blood pressure.

January 16, 2014: Got results of liver panel and we’re in normal range, so stopping I’m stopping Votrient for 14 days and taking Prilosec, carvedilol and Norvasc.

February 7, 2014: CT of chest, abdomen and pelvis shows completely stable and normal. Dr. Pippas says I’m NED again. Still tired, so he suggested I go back on nightly CPAP therapy and start some kind of exercise regimen. Also, wants me to maintain good immune system boosting diet and to not gain weight. At 155 pounds, about what I weighed when I left high school. Options presented to Jill and me:

A) stay off Votrient, scan every 3 months for a year
B) restart maintenance dose (either 200mg or 400mg) of Votrient

I asked Dr. Pippas to confer with Dr. Dan George at Duke, a colleague of his and someone who knows my case quite well. Also, I called Dena Battle, who knows this disease better than most doctors on the planet to ask her gut reaction to what doctor has advised. Made decision to stop taking Votrient.

July 22, 2014: CT scan with contrast shows 2.5cm metastasis on left adrenal. Same side as nephrectomy.

July 23, 2014: Discovered 2.5cm adrenal RCC metastasis and Dr. Pippas said surgery would be best option. We left the next day for a long weekend with friends in Destin, Fla.

August 6, 2014: Met with local surgeon Dr. Andy Roddenberry to discuss adrenalectomy procedure. Here’s an excerpt from my blog:

August 21, 2014: Excerpted blog post named “Eight Months:”  There is considerable scar tissue left over from the massive nephrectomy that cost me my left kidney, twelve lymph nodes and a lot of digging around looking for cancer. Additionally, the organs in my body have recognized that there is some stuff missing now that used to be there and they’ve wiggled around and taken up that space in my abdomen. So, scarring, colon, pancreas and a mass of arteries and veins are all congregated in that area, as well as a vascular renal cell tumor that is very much like a 2cm bubble of blood inside the thinnest tissue paper you can imagine. The surgery has been described to me like a person trying to pick up a balloon full of blood with razor sharp pins. One prick of that bubble and I’ve got cancer cells released all over my body and my prognosis suddenly would take a big turn for the worse.

We left Dr. Roddenberry’s office feeling the dread of making a decision to opt for a surgery that, even if successful, would really take me down physically and could significantly compromise my immune system. This is where the story gets really interesting, if you believe in karma. If you believe in a god, or if you worship from the torn front seat of a 1960 rusted, formerly white Chevrolet pickup at the 2nd Dirt Road Church of What’s Happening Now — this was the perfect information for me to hear at exactly the right time….

My friend, Dr. Granville Batte, called me and suggested we might want to meet with new Interventional Radiologist Dr. Nishant DeQuadros. That contact from a friend helped us find clarity. I promise you this: If you are a cancer patient who doesn’t have full faith in your doctor, and/or if you can’t see your a clear view of your feet along the path you have chosen, you are surely miserable. It is bad enough to feel bad, but to feel bad and be weighted down by stress related to your treatments makes the journey that much more difficult.

Here’s what I did to find that sweet spot of clarity before a new therapy: We made an appointment to meet Nishant DeQuadros and my work began. My doctors are my business partners. They provide a service that determines what is wrong with me and the crystal-clear vision backed up with the talent, experience and will to deliver a treatment path that will, at the very least cripple and at the very best in my case, completely shut down the disease process. I, and my insurance company pay them, their professional assistants and clinicians, staffs, technicians, labs, bean counters and hospitals. Then, the real work starts — research.

I fill whatever amount of time I can carve out prior to the first meeting with a new doctor with finding out everything I can about them. Where they’re from. Where they went to school. I seek out their professional writings, look for any feedback I can get from ratings sites, inquire of them with every one of my trusted medical sources and see if they have any kind of social media paper trail I can follow. I also like to find out who their friends are and if I happen to know them, I can’t pick our mutual friends’ brains to find out if they would put their life in the hands of this doctor. Melissa and Jim Thomas are friends of the DeQuadroses. That was a great thing to hear, right at the start.

I got a sweet surprise when I started vetting Dr. Nishant DeQuadros. The more I learned about him and his company, Georgia Radiology Imaging Consultants, the more excited I got. The doctors in this practice are extremely well trained. They do the kinds of procedures that are hard to come by in a community hospital setting. Often these highly-specialized radiologists are doing these kinds of procedures in larger urban or university hospitals. I found out later, just how important it was that these superdocs were here and that one of them was able to take my case.

Jill and I walked into Dr. DeQuadros’ office and a young, handsome guy in a white coat greeted us. We sat down, looked at my scans and we talked about how the ablation would be done. He brings mad experience to the table. At the end of that visit, we had that clarity that is so important.

August 28, 2014:  Interventional Radiologist Dr. DeQuadros and Anesthesiologist Dr. Mark Pinosky performed a microwave ablation of my left adrenal and its encapsulated RCC met. Complications during procedure caused Dr. DeQuadros to have to make four passes to get enough of a burn to completely finish the job. Disruption of my adrenal gland and the presence of the RCC metastasis caused a 300/200 blood pressure spike during the procedure. Because of the fear of cardiac damage from the BP spike, I spent the night in an intensive care room, so I could be monitored.

In my intensive care room the next morning after the procedure, I learned how serious the situation became during the minimally invasive operation. When they saw that I was having a major hypertensive reaction, Dr. DeQuadros ran a central line to my heart from behind me left knee, and, along with Dr. Pinosky, they monitored my blood pressure with every beat of my heart, utilizing drugs and procedures they had at their disposal to control wild blood pressure swings while still completing the procedure.

August 29, 2014: I was released with an appointment to see Dr. Shane Darrah to determine whether the high blood pressure had damaged my heart muscle.

September, 4, 2014: Saw Dr. Darrah and had stress test.

September 8, 2014: Had echocardiagram in Dr. Darrah’s office. It was determined that no heart damage resulted from blood pressure spike during microwave ablation.

October 2, 2014: CT scan with contrast (80% of dose). Still NED.

February 12, 2015: CT scan with contrast (80% of dose). Still NED.

The microwave ablation therapy I received here in Columbus was one of those cutting-edge treatments that can extend the life and protect the quality of life of a patient. In this process, I appreciated the candid advice given to me from Dr. Roddenberry that I should seek another, less invasive option that wouldn’t expose me to such a large, dangerous surgery that might negatively impact my compromised immune system. The incredible truth is that the huge surgery and the minimally-invasive microwave ablation should yield the same results (if perfectly executed). One would have cost me six days in the hospital and another six weeks of recovery. The other was performed on a Thursday and I was back in the office on Tuesday. I would have returned to work on Monday, had it not been the Labor Day holiday.

The list of vascular and interventional radiology treatments that are offered here by Drs. DeQuadros, Hart and Vo is quite long. If you receive a diagnosis that might be remedied by one of the treatments from this list like I did, you’d be wise to do a little Googleing to see if you might be better served by this type of care. Here’s the best part: When the therapy is finished, you can go home and sleep in your own bed. That is a mighty good thing.

April 30, 2015 | Tagged With: adrenalectomy, ASSURE trial, blood pressure, bone scan, brain MRI, carvedilol, Coreg, cpap, creatinine, CT scan, DaVinci robotic surgery, Dena Battle, dilaudid, Dr. Andy Pippas, Dr. Andy Roddenberry, Dr. Dan George, Dr. Granville Batte, Dr. Hoang Vo, Dr. James Hart, Dr. Ken Ogan, Dr. Lance Pagliaro, Dr. Marc Goldman, Dr. Mark Pinosky, Dr. Michael Gorum, Dr. MIchael Morse, Dr. Nishant deQuadros, Dr. Shane Darrah, Duke University Hospital, echocardiogram, Emory Midtown Hospital, Emory University Hospital, Georgia Radiology Imaging Consultants, HD IL2, Houston, insomnia, interventional radiology, John B. Amos Cancer Center, kidney cancer, laminectomy, liver toxicity, lumbar fusion, M. D. Anderson Cancer Center, medical oncologist, microwave ablation, Midtown Medical Center, morphine, MRI, NED, nephrectomy, Nexavar, Norvasc, placebo, Prilosec, radiation oncologist, renal cell carcinoma, stereotactic radiosurgery, stress test, Sutent, Votrient, Xgeva| Filed Under: Uncategorized | 1 Comment

Shaking Like Elvis

I have spent untold hours over the past 3.5 years in the infusion suite at the John B. Amos Cancer Center. While all the rest of the crowd has had destruction cloaked in sheep’s clothing dripping into their veins, I was always the pussy over in the corner with water coming down my drip line. I watched them wretch, release their bowels and sometimes be knocked flat by those cancer poisons releasing one drop at a time into their various ports, PICCs and IVs. You see, chemotherapy doesn’t work for renal cell carcinoma. I always felt like some kind of fake when I was in there being hydrated. That was an important procedure for me, but in the overall scheme of things, I felt like a bit fat pussy.

About 11 p.m. last night, I put on my big boy pants and joined the real infusion crowd. The first bag of aldesleukin (HD-IL2) was started about 6:30 yesterday evening. At exactly 11 p.m. Last night I jerked myself from a deep, REM sleep. My muscles were firing from my jawbone all the way through to the bottom of my feet. The rigors (for some reason here, pronounced Ryegers) hit me with a vengeance. I looked like a 240-pound marionette being controlled by one of Jerry’s kids. I couldn’t stop shaking until one of these nurse angels came in the door with a syringe filled with 2 mg of morphine. Two of those later, the shakes were gone and I drifted off to a great sleep in spite of the regular vital signs checks, but not before I was stricken with a bout of bodacious nausea. They came and dealt with that, too, and I managed to go to sleep without soiling myself or throwing up.  Mike 1 — HD-IL2 0!

They’re about to come and hang dose number three. They tell me these symptoms are cumulative and that I’ll be getting sicker and maybe quickly. My blood pressure is now about 95 over 50, so it has exhibited its expected slide. We’re going to get me into the shower as soon as Jill comes back from breakfast and get the wound changed where my PICC line went in.

I woke up this morning feeling really well. Wide awake, talkative and happy to be in the care of the beautiful Janet from Baltimore. These nurses here are truly incredible, just like the nurses in other institutions where I’ve had care. They are the ones on the line putting up with the patients and the doctors. A reluctant nurse sandwich. I have brought a load of my dad’s semi-world famous peanut brittle. That planned bag of sweet currency is helping to pay the bills around here.

So, with the third of dose of up to 14 in sight, we’re soldering on, one drip at a time. By the way, I found out the real reason to use a PICC line instead of a normal IV. Last night, I posted that the PICC goes in the antecubital (in the crook of your elbow) vein. It doesn’t. Mine went into the Basilic vein. Even though the wire tried to make an unscheduled side trip up my jugular vein into my neck, the nurse fished it back and had me contort my neck to force it over toward my heart at the superior vena cava. The reason a PICC line is used it to get the end of that catheter in the center of one of the largest veins in the body, the superior vena cava. That is done to properly dilute the medications in that big pipeline to better disperse them throughout the body.

I try to always learn something new each day. That is easy to do in a hospital.

September 4, 2012 | Tagged With: aldesleukin, antecubital vein, basilic vein, catheter, chemotherapy, Duke University Hospital, HD IL2, IV, John B. Amos Cancer Center, morphine, picc line, rigors, superior vena cava| Filed Under: kidney cancer | 17 Comments

E.D. (Hint: Doesn’t Stand for Erectile Dysfunction)

Yesterday morning, Jill and I decided we were on the road to nowhere. A call to Dr. Pippas and an explanation of the depth of my exhaustion and the severity of my pain sent us packing to the beautiful, newly-renovated and improved E.D. (Hint: does stand for emergency department) at The Medical Center. Although I’ve seen photographs of the $25 million dollar renovation project, this is the first I’ve seen it with my own eyes. Even though I was in big time pain, I could see the fabulous work that has been done.

The waiting room is huge, bright and nicely appointed. I like the colors that were chosen. Despite the beauty of the front of the house, the waiting room was just a small taste of the wow factor that appeared as we pushed through the doors to the business end of the new emergency department. WOW! Wide, well-lit halls and a double handful of private rooms with flat screen TVs. I remember the old emergency room at The Medical Center. What an incredible transformation.

It is a good thing we liked the new look, because we were there all day. We were an unexpected part of Dr. Pippas’ day on Monday, so I’m not bitching about the length of time it took to get us into a room. He decided that I needed to be admitted to get a good look at what might be the source of my debilitating pain and to put together a pain management plan to be able to deal with it at home, a place that doesn’t offer intravenous pain medication.

They got me comfortable as soon as we hit our room in the emergency department with IV demerol and something to prevent nausea. Dr. Drew Williams runs the place and he was hands on with us from the minute we arrived. Thank you Dr. Drew! Finally, out of pain for the first time in many, many days. Dr. Gorum and his affable PA, Henry Aucoin stopped by to check on me and to order a CT scan to inspect the results of their very difficult surgery of three weeks ago. After much scrutiny, they came to report that my newly-rebuilt lumbar spine is spot-on and exactly where they left it before the seven incisions were closed.

I got an interesting explanation of my “innerds” as Dr. Gorum called them. I love it when really smart, gifted brain surgeons can be real people and bring their personalities to their job. Dr. Mike Gorum is as real as they get. So talented and I’ll tell you that I’ve seen him in action with a few people I know and also with a few people whom I love and they will all tell you that he is always reluctant to operate. Imagine that, a surgeon who operates only as a last resort. I don’t know about you, but I want that kind of restraint from my neurosurgeon.

As a disclaimer, I want to report that Mike and I are also friends. I’ve ridden quite a few miles of road with Mike Gorum on our bicycles, too. The man never gives up! “Hey, let’s race to that sign up there.” “Hey, I’ll race you to the top of that hill over there.” You know what? I also want that kind of take-no-prisoners competitiveness in my neurosurgeon.

So, Dr. Gorum tells me today that I’m possibly the most muscular patient he’s EVER operated on. It is my psoas muscles. He says I have “enormous” psoas muscles. Henry put it a different way. Henry said I’d have made great tenderloins. These guys crack me up! The psoas is the same muscle as the beef tenderloins. They run down both sides of the backbone of the critters that we eat and also in us humans.

My “honkin'” psoas muscles had to be negotiated during my surgery and the one on my right is angry and inflamed. That is the source of my pain and I am confident after a meeting with my surgical team that it will settle down after the time it needs to get back to normal.

When we got settled in our hospital room last evening, they brought out the big guns. IV dilaudid for pain and ativan to help me sleep. Only one dose of the pain medication and I was given the wonderful gift of 10 hours of sleep. Ensley, the nurse manager on the 7th floor had a hospital bed rolled into my room and Jill finally got a complete night of sleep, too. Her nights of sleep have been cut short lately dealing with me. If they gave out an academy award for spouses, she would win in two categories: Best Wife on Earth and the lifetime achievement award for Most Patient Wife on Earth. Her long-sufferingness has exacted a toll on her that I haven’t taken for granted. I also want every person within the sound of my real voice, my blog voice and my Facebook voice to know that I appreciate every little thing she does to show how much she loves me.

I don’t know many women who could have done all the things she’s done to keep our business on track, and been a perfect mother to our four sons, a great daughter to her mom and a leader in our community and in our church and a loving, long-suffering spouse of a sick, needy man and to have done all of this with such grace. How, oh how, did I ever deserve Jill Tigner? I love you, possum. I hope we get many, many more years together for me to sicken people with my unabashed love for you.

We left the hospital this afternoon with several things accomplished. We have a pain management plan in place that has me taking some high-powered pain killers that are time-released and should provide steady, pain abatement while leaving me clear headed for work and able to go about my daily life until my psoas muscle decides to settle down and stop causing me pain.

Tonight is a first night run at home. I’ve taken the 12-hour pill and I plan to utilize the ativan to get to sleep. I need a homerun of sleep tonight to get back my confidence that I can even get a good night’s sleep at home. It has been two weeks of pacing at night and catching hour long naps in every chair and sofa in our home. I need a good one tonight.

The second thing we got done today is after a long conversation with Dr. Andrew Pippas, we have decided to go back to Emory for consultation with Dr. Stapleford and another likely stereotactic radiosurgery treatment to my spine at L-1 and for an extra advice from another expert spine surgeon Dr. Sandro LaRocca, MD, who saw some additional tumor in that same area in my spine and told us that he felt the radiosurgery was a much better option to remove it than traditional surgery. Again, that restraint. I’m so thankful that my neurosurgeon has the good judgement to know when even his bright mind and steady hands might not be the best thing for their patient.

So, were going back to Emory. Soon. And, Dr. Pippas’ office is helping us put together two files on my case to send on to Dr. Janice Dutcher at Roosevelt Hospital in Manhattan, New York City and Dr. Dan George at Duke University hospital. They are two nationally known renal cell cancer specialists who will weigh in on our future treatment options. I’m especially interested in high dose interleukin 2 (HDIL-2). Google it if you have the stomach for it. It is a brutal regimen of treatment, but it is something I might have to undergo.

I am in this to win it. With my healthcare team, a loving family and a network of friends of epic proportion, we take another step down this scary, but thankfully not lonely road. I’m sorry for the length of this post, but like Jill just said to me, “a lot has happened in the last two days.”

We continue to appreciate your love and your comments to this blog. Jill and I read them together and we know they are a source of so much good for our sons and our parents to know that so many people care for and support us.

Goodnight…and if you see another post from me before the sun comes up tomorrow, I will not be in a very good mood.

Damn cancer. DAMN CANCER! (Thank you, Judy Walsh, for these very direct and eloquent words.) I couldn’t agree with you more.

September 13, 2011 | Tagged With: ativan, demerol, dilaudid, Dr. Andrew Pippas, Dr. Dan George, Dr. Drew Williams, Dr. Janice Dutcher, Dr. Liza Stapleford, Dr. Mike Gorum, Duke University Hospital, Emory, Ensley, Henry Aucoin PA, High Dose Interleukin-2, Jill Tigner, Judy Walsh, morphine, Roosevelt Hospital, stereotactic radiosurgery, The Medical Center Emergency Department| Filed Under: kidney cancer | 37 Comments

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